This data set is the result of dynamic downscaling simulation of CORDEX region 8 (Central Asia) using WRF model driven by MPI-ESM-HR1.2 model data in CMIP6 plan. The data include 2m temperature (variable T2) and precipitation and precipitation was divided into convective (variable RAINC) and non-convective (variable RAINNC) precipitation. The time period includes historical test (1995-2014), near future (2021-2040) and medium future (2041-2060). The future time period includes SSP1-2.6 and SSP5-8.5. The time resolution of the simulation is once every 6 hours, the spatial resolution is 25km, the number of vertical layers is 51, a whole year in 1994 is used as spin up, the SST update is used, and the parameterized scheme combination with good performance in this area is selected. The data set can better reflect the future climate change characteristics of Central Asia and the Qinghai Tibet Plateau, and provide guidance for relevant countries to adapt to climate change.